ATPB_HUMAN

Source: hRBCD ; ID: IPI00303476
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: ATP5B , ATPMB, ATPSB
Protein names and data: ATPB_HUMAN , ATP synthase subunit beta, mitochondrial; 3.6.3.14; Flags: Precursor Lenght: 529 a.a.
Mass: 56560 Da
fasta formatted sequence
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Catalytic activity: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
Cellular location: Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.

Genetic variants

Database cross-references

UniProt: P06576
Ensembl: ENST00000262030
MIM: 102910
neXtProt: NX_P06576
Antibodypedia: P06576 (may not find the protein thus also not any antibody)
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