ATRAP_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AGTRAP , ATRAP
Protein names and data: ATRAP_HUMAN , Type-1 angiotensin II receptor-associated protein , AT1 receptor-associated protein Lenght: 159 a.a.
Mass: 17419 Da
fasta formatted sequence
Function: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Tissue specificity: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.

Genetic variants

Database cross-references

UniProt: Q6RW13
Ensembl: ENST00000314340
Ensembl: ENST00000376629
Ensembl: ENST00000376637
Ensembl: ENST00000400895
Ensembl: ENST00000452018
MIM: 608729
neXtProt: NX_Q6RW13
Antibodypedia: Q6RW13 (may not find the protein thus also not any antibody)
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