Source: PM19886704
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: BCL2L1 , BCL2L, BCLX
Protein names and data: B2CL1_HUMAN , Bcl-2-like protein 1; Bcl2-L-1 , Apoptosis regulator Bcl-X Lenght: 233 a.a.
Mass: 26049 Da
fasta formatted sequence

Function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. Isoform Bcl-X(S) promotes apoptosis.
Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane (By similarity). Mitochondrion outer membrane (By similarity). Mitochondrion matrix (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.
Tissue specificity: Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Database cross-references

UniProt: Q07817
Ensembl: ENST00000307677
Ensembl: ENST00000376055
Ensembl: ENST00000376062
Ensembl: ENST00000420653
MIM: 600039
neXtProt: NX_Q07817
Antibodypedia: Q07817 (may not find the protein thus also not any antibody)
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