BACH_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ACOT7 , BACH
Protein names and data: BACH_HUMAN , Cytosolic acyl coenzyme A thioester hydrolase; 3.1.2.2 , Acyl-CoA thioesterase 7; Brain acyl-CoA hydrolase; BACH; CTE-IIa; CTE-II; Long chain acyl-CoA thioester hydrolase Lenght: 380 a.a.
Mass: 41796 Da
fasta formatted sequence
Function: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate.
Cellular location: Isoform 4: Cytoplasm. Isoform 6: Cytoplasm. Isoform 1: Mitochondrion. Isoform 5: Mitochondrion.
Tissue specificity: Isoform 4 is expressed exclusively in brain.

Database cross-references

UniProt: O00154
Ensembl: ENST00000361521
Ensembl: ENST00000377842
Ensembl: ENST00000377845
Ensembl: ENST00000377855
Ensembl: ENST00000377860
Ensembl: ENST00000418124
MIM: 602587
neXtProt: NX_O00154
Antibodypedia: O00154 (may not find the protein thus also not any antibody)
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