BAD_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: BAD , BBC6, BCL2L8
Protein names and data: BAD_HUMAN , Bcl2 antagonist of cell death; BAD , Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter Lenght: 168 a.a.
Mass: 18392 Da
fasta formatted sequence
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Cellular location: Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.
Tissue specificity: Expressed in a wide variety of tissues.

Genetic variants

Database cross-references

UniProt: Q92934
Ensembl: ENST00000309032
Ensembl: ENST00000394532
MIM: 603167
neXtProt: NX_Q92934
Antibodypedia: Q92934 (may not find the protein thus also not any antibody)
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