Source: hRBCD ; ID: IPI00019906
BGMUT ; ID: ok
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: BSG , UNQ6505/PRO21383
Protein names and data: BASI_HUMAN , Basigin , 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; CD147; Flags: Precursor Lenght: 385 a.a.
Mass: 42200 Da
fasta formatted sequence

Function: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity).
Cellular location: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue specificity: Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Genetic variants

Database cross-references

UniProt: P35613
Ensembl: ENST00000333511
Ensembl: ENST00000346916
Ensembl: ENST00000353555
Ensembl: ENST00000545507
MIM: 109480
MIM: 111380
neXtProt: NX_P35613
Antibodypedia: P35613 (may not find the protein thus also not any antibody)
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