BLMH_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: BLMH
Protein names and data: BLMH_HUMAN , Bleomycin hydrolase; BH; BLM hydrolase; BMH; 3.4.22.40 Lenght: 455 a.a.
Mass: 52562 Da
fasta formatted sequence
Function: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity).
Catalytic activity: Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta- aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
Cellular location: Cytoplasm.

Genetic variants

Database cross-references

UniProt: Q13867
Ensembl: ENST00000261714
MIM: 602403
neXtProt: NX_Q13867
Antibodypedia: Q13867 (may not find the protein thus also not any antibody)
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