BLVRB_HUMAN

Source: hRBCD ; ID: IPI00219910
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: BLVRB , FLR
Protein names and data: BLVRB_HUMAN , Flavin reductase (NADPH); FR; 1.5.1.30 , Biliverdin reductase B; BVR-B; 1.3.1.24; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR Lenght: 206 a.a.
Mass: 22119 Da
fasta formatted sequence
Function: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Catalytic activity: Reduced riboflavin + NADP(+) = riboflavin + NADPH. Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H.
Cellular location: Cytoplasm.
Tissue specificity: Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum.

Genetic variants

Database cross-references

UniProt: P30043
Ensembl: ENST00000263368
MIM: 600941
neXtProt: NX_P30043
Antibodypedia: P30043 (may not find the protein thus also not any antibody)
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