BMI1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: BMI1 , PCGF4, RNF51
Protein names and data: BMI1_HUMAN , Polycomb complex protein BMI-1 , Polycomb group RING finger protein 4; RING finger protein 51 Lenght: 326 a.a.
Mass: 36949 Da
fasta formatted sequence
Function: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Cellular location: Nucleus. Cytoplasm.

Genetic variants

Database cross-references

UniProt: P35226
Ensembl: ENST00000376663
MIM: 164831
neXtProt: NX_P35226
Antibodypedia: P35226 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.