Source: BSc_CH
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: BPI
Protein names and data: BPI_HUMAN , Bactericidal permeability-increasing protein; BPI , CAP 57; Flags: Precursor Lenght: 487 a.a.
Mass: 53900 Da
fasta formatted sequence

Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Cellular location: Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Tissue specificity: Restricted to cells of the myeloid series.

Genetic variants

Database cross-references

UniProt: P17213
Ensembl: ENST00000262865
MIM: 109195
neXtProt: NX_P17213
Antibodypedia: P17213 (may not find the protein thus also not any antibody)
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