RBCC Red Blood Cell Collection

BPI_HUMAN

Source: BSc_CH
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: BPI
Protein names and data: BPI_HUMAN , Bactericidal permeability-increasing protein; BPI , CAP 57; Flags: Precursor Lenght: 487 a.a.
Mass: 53900 Da
fasta formatted sequence
Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Cellular location: Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Tissue specificity: Restricted to cells of the myeloid series.

Genetic variants

12 - 12 A -> T (in dbSNP:rs5743497). VAR_049728 5743497
12 - 12 A -> V (in dbSNP:rs5743498). VAR_049729 5743498
16 - 16 A -> V (in dbSNP:rs1341023). VAR_018401 1341023
90 - 90 R -> C (in dbSNP:rs5743500). VAR_049730 5743500
140 - 140 E -> Q (in dbSNP:rs5743506). VAR_049732 5743506
196 - 196 A -> V (in dbSNP:rs5743509). VAR_018402 5743509
216 - 216 E -> K (in dbSNP:rs4358188). VAR_018403 4358188
280 - 280 A -> V (in dbSNP:rs5741804). VAR_049733 5741804
377 - 377 V -> I (in dbSNP:rs5743524). VAR_049734 5743524
404 - 404 N -> D (in dbSNP:rs5741809). VAR_049735 5741809
451 - 451 K -> E (in dbSNP:rs5743542). VAR_049736 5743542

Database cross-references

UniProt: P17213
Ensembl: ENST00000262865
MIM: 109195
neXtProt: NX_P17213
Antibodypedia: P17213 (may not find the protein thus also not any antibody)
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