BRCC3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: BRCC3 , BRCC36, C6.1A, CXorf53
Protein names and data: BRCC3_HUMAN , Lys-63-specific deubiquitinase BRCC36; 3.4.19.- , BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36 Lenght: 316 a.a.
Mass: 36072 Da
fasta formatted sequence
Function: Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.
Disease:
Cellular location: Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors.

Genetic variants

Database cross-references

UniProt: P46736
Ensembl: ENST00000330045
Ensembl: ENST00000340647
Ensembl: ENST00000369459
Ensembl: ENST00000369462
Ensembl: ENST00000594541
Ensembl: ENST00000597217
Ensembl: ENST00000597826
Ensembl: ENST00000601378
MIM: 300617
neXtProt: NX_P46736
Antibodypedia: P46736 (may not find the protein thus also not any antibody)
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