BRE_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: BRE , BRCC45
Protein names and data: BRE_HUMAN , BRCA1-A complex subunit BRE , BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein Lenght: 383 a.a.
Mass: 43552 Da
fasta formatted sequence
Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
Cellular location: Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue specificity: Expressed in all cell lines examined. Highly expressed in placenta.

Database cross-references

UniProt: Q9NXR7
Ensembl: ENST00000342045
Ensembl: ENST00000344773
Ensembl: ENST00000361704
Ensembl: ENST00000379624
Ensembl: ENST00000379632
MIM: 610497
neXtProt: NX_Q9NXR7
Antibodypedia: Q9NXR7 (may not find the protein thus also not any antibody)
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