Source: PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: CDC42SE2 , SPEC2
Protein names and data: C42S2_HUMAN , CDC42 small effector protein 2 , Small effector of CDC42 protein 2 Lenght: 84 a.a.
Mass: 9223 Da
fasta formatted sequence

Function: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
Cellular location: Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
Tissue specificity: Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).

Database cross-references

UniProt: Q9NRR3
Ensembl: ENST00000360515
Ensembl: ENST00000395246
Ensembl: ENST00000505065
neXtProt: NX_Q9NRR3
Antibodypedia: Q9NRR3 (may not find the protein thus also not any antibody)
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