C4BPA_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: C4BPA , C4BP
Protein names and data: C4BPA_HUMAN , C4b-binding protein alpha chain; C4bp , Proline-rich protein; PRP; Flags: Precursor Lenght: 597 a.a.
Mass: 67033 Da
fasta formatted sequence
Function: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
Cellular location: Secreted.
Tissue specificity: Chylomicrons in the plasma.

Genetic variants

Database cross-references

UniProt: P04003
Ensembl: ENST00000367070
MIM: 120830
neXtProt: NX_P04003
Antibodypedia: P04003 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.