CACO1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CALCOCO1 , KIAA1536 , PP13275, UNQ2436/PRO4996
Protein names and data: CACO1_HUMAN , Calcium-binding and coiled-coil domain-containing protein 1 , Calphoglin; Coiled-coil coactivator protein; Sarcoma antigen NY-SAR-3 Lenght: 691 a.a.
Mass: 77336 Da
fasta formatted sequence
Function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.
Cellular location: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm (By similarity).

Genetic variants

Database cross-references

UniProt: Q9P1Z2
Ensembl: ENST00000262059
Ensembl: ENST00000430117
Ensembl: ENST00000548263
Ensembl: ENST00000550804
neXtProt: NX_Q9P1Z2
Antibodypedia: Q9P1Z2 (may not find the protein thus also not any antibody)
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