Source: hRBCD ; ID: IPI00218414
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: CA2
Protein names and data: CAH2_HUMAN , Carbonic anhydrase 2; , Carbonate dehydratase II; Carbonic anhydrase C; CAC; Carbonic anhydrase II; CA-II Lenght: 260 a.a.
Mass: 29246 Da
fasta formatted sequence

Function: Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.
Cellular location: Cytoplasm. Cell membrane. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.

Genetic variants

Database cross-references

UniProt: P00918
Ensembl: ENST00000285379
MIM: 259730
MIM: 611492
neXtProt: NX_P00918
Antibodypedia: P00918 (may not find the protein thus also not any antibody)
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