CALR_HUMAN

Source: hRBCD ; ID: IPI00020599
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CALR , CRTC
Protein names and data: CALR_HUMAN , Calreticulin , CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP; grp60; Flags: Precursor Lenght: 417 a.a.
Mass: 48142 Da
fasta formatted sequence
Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
Cellular location: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen (By similarity). Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.

Database cross-references

UniProt: P27797
Ensembl: ENST00000316448
MIM: 109091
neXtProt: NX_P27797
Antibodypedia: P27797 (may not find the protein thus also not any antibody)
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