Source: hRBCD ; ID: IPI00020984
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: CANX
Protein names and data: CALX_HUMAN , Calnexin , IP90; Major histocompatibility complex class I antigen-binding protein p88; p90; Flags: Precursor Lenght: 592 a.a.
Mass: 67568 Da
fasta formatted sequence

Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.
Cellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes to the perinuclear rough ER.

Database cross-references

UniProt: P27824
Ensembl: ENST00000247461
Ensembl: ENST00000452673
Ensembl: ENST00000504734
MIM: 114217
neXtProt: NX_P27824
Antibodypedia: P27824 (may not find the protein thus also not any antibody)
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