CAND1_HUMAN

Source: hRBCD ; ID: IPI00100160
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CAND1 , KIAA0829, TIP120, TIP120A
Protein names and data: CAND1_HUMAN , Cullin-associated NEDD8-dissociated protein 1 , Cullin-associated and neddylation-dissociated protein 1; TBP-interacting protein of 120 kDa A; TBP-interacting protein 120A; p120 CAND1 Lenght: 1230 a.a.
Mass: 136376 Da
fasta formatted sequence
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Cellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.

Genetic variants

Database cross-references

UniProt: Q86VP6
Ensembl: ENST00000544619
Ensembl: ENST00000545606
MIM: 607727
neXtProt: NX_Q86VP6
Antibodypedia: Q86VP6 (may not find the protein thus also not any antibody)
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