CAP7_HUMAN

Source: BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: AZU1
Protein names and data: CAP7_HUMAN , Azurocidin , Cationic antimicrobial protein CAP37; Heparin-binding protein; HBP; Flags: Precursor Lenght: 251 a.a.
Mass: 26886 Da
fasta formatted sequence
Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
Cellular location: Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils.

Genetic variants

Database cross-references

UniProt: P20160
Ensembl: ENST00000233997
MIM: 162815
neXtProt: NX_P20160
Antibodypedia: P20160 (may not find the protein thus also not any antibody)
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