CASPE_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CASP14
Protein names and data: CASPE_HUMAN , Caspase-14; CASP-14; 3.4.22.-; Caspase-14 subunit p19; Caspase-14 subunit p10; Flags: Precursor Lenght: 242 a.a.
Mass: 27680 Da
fasta formatted sequence
Function: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity).
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels.

Database cross-references

UniProt: P31944
Ensembl: ENST00000221740
Ensembl: ENST00000427043
MIM: 605848
neXtProt: NX_P31944
Antibodypedia: P31944 (may not find the protein thus also not any antibody)
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