CATE_HUMAN

Source: PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CTSE
Protein names and data: CATE_HUMAN , Cathepsin E; 3.4.23.34; Cathepsin E form I; Cathepsin E form II; Flags: Precursor Lenght: 401 a.a.
Mass: 43312 Da
fasta formatted sequence
Function: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Catalytic activity: Similar to cathepsin D, but slightly broader specificity.
Cellular location: Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Tissue specificity: Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes.

Genetic variants

Database cross-references

UniProt: P14091
Ensembl: ENST00000358184
Ensembl: ENST00000360218
Ensembl: ENST00000581049
Ensembl: ENST00000583663
MIM: 116890
neXtProt: NX_P14091
Antibodypedia: P14091 (may not find the protein thus also not any antibody)
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