CBR1_HUMAN

Source: hRBCD ; ID: IPI00295386
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CBR1 , CBR, CRN
Protein names and data: CBR1_HUMAN , Carbonyl reductase [NADPH] 1; 1.1.1.184 , 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; 1.1.1.197; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase; 1.1.1.189 Lenght: 277 a.a.
Mass: 30375 Da
fasta formatted sequence
Function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Catalytic activity: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. (5Z,13E)-(15S)-9-alpha,11-alpha,15- trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11- alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost- 13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13- enoate + NADPH.
Cellular location: Cytoplasm.

Genetic variants

Database cross-references

UniProt: P16152
Ensembl: ENST00000290349
MIM: 114830
neXtProt: NX_P16152
Antibodypedia: P16152 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.