CCRL2_HUMAN

Source: PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CCRL2 , CCR11, CCR6, CKRX, CRAM, HCR
Protein names and data: CCRL2_HUMAN , C-C chemokine receptor-like 2 , Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor Lenght: 344 a.a.
Mass: 39513 Da
fasta formatted sequence
Function: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Cellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.

Genetic variants

Database cross-references

UniProt: O00421
MIM: 608379
neXtProt: NX_O00421
Antibodypedia: O00421 (may not find the protein thus also not any antibody)
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