Source: BD_CD
Marked as 'Membrane associated protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: CD109 , CPAMD7
Protein names and data: CD109_HUMAN , CD109 antigen , 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Platelet-specific Gov antigen; p180; r150; CD109; Flags: Precursor Lenght: 1445 a.a.
Mass: 161689 Da
fasta formatted sequence

Function: Modulates negatively TGFB1 signaling in keratinocytes.
Cellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue specificity: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.

Genetic variants

The Gov(b) variant in position 703 defines the Gov alloantigenic determinants.

Database cross-references

UniProt: Q6YHK3
Ensembl: ENST00000287097
Ensembl: ENST00000422508
Ensembl: ENST00000437994
MIM: 608859
neXtProt: NX_Q6YHK3
Antibodypedia: Q6YHK3 (may not find the protein thus also not any antibody)
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