CD14_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CD14
Protein names and data: CD14_HUMAN , Monocyte differentiation antigen CD14 , Myeloid cell-specific leucine-rich glycoprotein; CD14; Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form; Flags: Precursor Lenght: 375 a.a.
Mass: 40076 Da
fasta formatted sequence
Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
Cellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue specificity: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Genetic variants

Database cross-references

UniProt: P08571
Ensembl: ENST00000302014
Ensembl: ENST00000401743
MIM: 158120
neXtProt: NX_P08571
Antibodypedia: P08571 (may not find the protein thus also not any antibody)
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