Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: CD2AP
Protein names and data: CD2AP_HUMAN , CD2-associated protein , Adapter protein CMS; Cas ligand with multiple SH3 domains Lenght: 639 a.a.
Mass: 71451 Da
fasta formatted sequence

Function: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
Cellular location: Cytoplasm, cytoskeleton (By similarity). Cell projection, ruffle (By similarity). Note=Colocalizes with F- actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.
Tissue specificity: Widely expressed in fetal and adult tissues.

Genetic variants

Database cross-references

UniProt: Q9Y5K6
Ensembl: ENST00000359314
MIM: 604241
MIM: 607832
neXtProt: NX_Q9Y5K6
Antibodypedia: Q9Y5K6 (may not find the protein thus also not any antibody)
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