CD36_HUMAN
Source:
BSc_CH
Marked as 'Integral membrane protein'
Confidence:
medium (present in either hRBCD or BSc_CH or PM22954596)
Search PubMed for
(RBC AND this entry)
Gene names:
CD36
, GP3B, GP4
Protein names and data:
CD36_HUMAN
, Platelet glycoprotein 4
, Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD36
Lenght: 472 a.a.
Mass: 53053 Da
fasta formatted sequence
Function:
Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects.
Disease:
( OMIM:
173510
248310
608404
610938
611162
)
Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Note=The disease is caused by mutations affecting the gene represented in this entry. Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Cellular location:
Membrane; Multi-pass membrane protein.
Genetic variants
Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIM:611162].
90 - 90
P -> S (in PG4D; type I; degradation in the cytoplasm due to defects in maturation; dbSNP:rs3765187). VAR_017913
3765187
123 - 123
E -> K (in individuals from a malaria endemic area in West Africa; dbSNP:rs183461468). VAR_017914
183461468
127 - 127
S -> L (in dbSNP:rs201765331). VAR_019049
201765331
154 - 154
V -> F (in dbSNP:rs5957). VAR_013918
5957
174 - 174
T -> A (in individuals from a malaria endemic area in West Africa). VAR_017915
232 - 232
G -> GN (in individuals from a malaria endemic area in West Africa). VAR_017916
254 - 254
F -> L (in PG4D; type I; dbSNP:rs142186404). VAR_017917
142186404
271 - 271
I -> T (in individuals from a malaria endemic area in West Africa). VAR_017918
413 - 413
I -> L (in PG4D; type I). VAR_017919
Database cross-references
UniProt:
P16671
Ensembl:
ENST00000309881
Ensembl:
ENST00000394788
Ensembl:
ENST00000432207
Ensembl:
ENST00000435819
Ensembl:
ENST00000447544
MIM:
173510
MIM:
248310
MIM:
608404
MIM:
610938
MIM:
611162
neXtProt:
NX_P16671
Antibodypedia:
P16671
(may not find the protein thus also not any antibody)
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