Source: hRBCD ; ID: IPI00297160
BGMUT ; ID: indian
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: CD44 , LHR, MDU2, MDU3, MIC4
Protein names and data: CD44_HUMAN , CD44 antigen , CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD44; Flags: Precursor Lenght: 742 a.a.
Mass: 81538 Da
fasta formatted sequence

Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
Cellular location: Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges (By similarity).
Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Genetic variants

CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46.

Database cross-references

UniProt: P16070
Ensembl: ENST00000263398
Ensembl: ENST00000278386
Ensembl: ENST00000352818
Ensembl: ENST00000360158
Ensembl: ENST00000415148
Ensembl: ENST00000428726
Ensembl: ENST00000433892
Ensembl: ENST00000434472
Ensembl: ENST00000437706
Ensembl: ENST00000449691
MIM: 107269
MIM: 172290
MIM: 609027
neXtProt: NX_P16070
Antibodypedia: P16070 (may not find the protein thus also not any antibody)
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