CD47_HUMAN

Source: hRBCD ; ID: IPI00216514
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CD47 , MER6
Protein names and data: CD47_HUMAN , Leukocyte surface antigen CD47 , Antigenic surface determinant protein OA3; Integrin-associated protein; IAP; Protein MER6; CD47; Flags: Precursor Lenght: 323 a.a.
Mass: 35214 Da
fasta formatted sequence
Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Cellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Database cross-references

UniProt: Q08722
Ensembl: ENST00000355354
Ensembl: ENST00000361309
MIM: 601028
neXtProt: NX_Q08722
Antibodypedia: Q08722 (may not find the protein thus also not any antibody)
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