CD59_HUMAN

Source: hRBCD ; ID: IPI00011302
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CD59 , MIC11, MIN1, MIN2, MIN3, MSK21
Protein names and data: CD59_HUMAN , CD59 glycoprotein , 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD59; Flags: Precursor Lenght: 128 a.a.
Mass: 14177 Da
fasta formatted sequence
Function: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
Disease:
Cellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues.

Genetic variants

Database cross-references

UniProt: P13987
Ensembl: ENST00000351554
Ensembl: ENST00000395850
Ensembl: ENST00000415002
Ensembl: ENST00000426650
Ensembl: ENST00000437761
Ensembl: ENST00000445143
Ensembl: ENST00000525763
Ensembl: ENST00000527577
Ensembl: ENST00000528700
MIM: 107271
MIM: 612300
neXtProt: NX_P13987
Antibodypedia: P13987 (may not find the protein thus also not any antibody)
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