CDC42_HUMAN

Source: hRBCD ; ID: IPI00016786
PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CDC42
Protein names and data: CDC42_HUMAN , Cell division control protein 42 homolog , G25K GTP-binding protein; Flags: Precursor Lenght: 191 a.a.
Mass: 21259 Da
fasta formatted sequence
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.
Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.

Database cross-references

UniProt: P60953
Ensembl: ENST00000315554
Ensembl: ENST00000344548
Ensembl: ENST00000400259
MIM: 116952
neXtProt: NX_P60953
Antibodypedia: P60953 (may not find the protein thus also not any antibody)
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