CDK13_HUMAN

Source: PM19886704
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CDK13 , CDC2L, CDC2L5, CHED, KIAA1791
Protein names and data: CDK13_HUMAN , Cyclin-dependent kinase 13; 2.7.11.22; 2.7.11.23 , CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; hCDK13; Cholinesterase-related cell division controller Lenght: 1512 a.a.
Mass: 164923 Da
fasta formatted sequence
Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys- 51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. ATP + a protein = ADP + a phosphoprotein.
Cellular location: Nucleus speckle.
Tissue specificity: Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

Genetic variants

Database cross-references

UniProt: Q14004
Ensembl: ENST00000181839
Ensembl: ENST00000340829
MIM: 603309
neXtProt: NX_Q14004
Antibodypedia: Q14004 (may not find the protein thus also not any antibody)
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