CHCH3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CHCHD3 , MINOS3
Protein names and data: CHCH3_HUMAN , Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial Lenght: 227 a.a.
Mass: 26152 Da
fasta formatted sequence
Function: Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription.
Cellular location: Mitochondrion inner membrane; Lipid-anchor; Intermembrane side (By similarity). Cytoplasm. Nucleus.
Tissue specificity: Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue.

Database cross-references

UniProt: Q9NX63
Ensembl: ENST00000262570
MIM: 613748
neXtProt: NX_Q9NX63
Antibodypedia: Q9NX63 (may not find the protein thus also not any antibody)
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