Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: CHMP6 , VPS20
Protein names and data: CHMP6_HUMAN , Charged multivesicular body protein 6 , Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20 Lenght: 201 a.a.
Mass: 23485 Da
fasta formatted sequence

Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
Cellular location: Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane (Probable). Note=Localizes to endosomal membranes.
Tissue specificity: Ubiquitously expressed.

Genetic variants

Database cross-references

UniProt: Q96FZ7
Ensembl: ENST00000325167
MIM: 610901
neXtProt: NX_Q96FZ7
Antibodypedia: Q96FZ7 (may not find the protein thus also not any antibody)
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