CHP3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TESC , CHP3
Protein names and data: CHP3_HUMAN , Calcineurin B homologous protein 3 , Tescalcin; TSC Lenght: 214 a.a.
Mass: 24750 Da
fasta formatted sequence
Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Cellular location: Nucleus. Cytoplasm. Membrane (By similarity). Cell membrane. Cell projection, lamellipodium (By similarity). Cell projection, ruffle membrane (By similarity). Note=Colocalizes with SLC9A1 at the plasma membrane.
Tissue specificity: Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.

Database cross-references

UniProt: Q96BS2
Ensembl: ENST00000335209
Ensembl: ENST00000470612
Ensembl: ENST00000541210
MIM: 611585
neXtProt: NX_Q96BS2
Antibodypedia: Q96BS2 (may not find the protein thus also not any antibody)
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