CHRD1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CHORDC1 , CHP1
Protein names and data: CHRD1_HUMAN , Cysteine and histidine-rich domain-containing protein 1 , CHORD domain-containing protein 1; CHORD-containing protein 1; CHP-1; Protein morgana Lenght: 332 a.a.
Mass: 37490 Da
fasta formatted sequence
Function: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
Tissue specificity: Underexpressed in many breast and lung cancers.

Genetic variants

Database cross-references

UniProt: Q9UHD1
Ensembl: ENST00000320585
Ensembl: ENST00000457199
MIM: 604353
neXtProt: NX_Q9UHD1
Antibodypedia: Q9UHD1 (may not find the protein thus also not any antibody)
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