Source: hRBCD ; ID: IPI00018451
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: CIB1 , CIB, KIP, PRKDCIP
Protein names and data: CIB1_HUMAN , Calcium and integrin-binding protein 1; CIB , Calcium- and integrin-binding protein; CIBP; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; SNK-interacting protein 2-28; SIP2-28 Lenght: 191 a.a.
Mass: 21703 Da
fasta formatted sequence

Function: May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.
Cellular location: Membrane; Lipid-anchor. Cytoplasm. Nucleus. Cell projection, filopodium. Apical cell membrane. Note=Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q99828
Ensembl: ENST00000328649
MIM: 602293
neXtProt: NX_Q99828
Antibodypedia: Q99828 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.