CIRBP_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CIRBP , A18HNRNP, CIRP
Protein names and data: CIRBP_HUMAN , Cold-inducible RNA-binding protein , A18 hnRNP; Glycine-rich RNA-binding protein CIRP Lenght: 172 a.a.
Mass: 18648 Da
fasta formatted sequence
Function: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
Cellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
Tissue specificity: Ubiquitous.

Database cross-references

UniProt: Q14011
Ensembl: ENST00000320936
Ensembl: ENST00000585630
Ensembl: ENST00000586472
Ensembl: ENST00000588030
Ensembl: ENST00000588090
Ensembl: ENST00000589660
MIM: 602649
neXtProt: NX_Q14011
Antibodypedia: Q14011 (may not find the protein thus also not any antibody)
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