CISD2_HUMAN

Source: hRBCD ; ID: IPI00166865
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CISD2 , CDGSH2, ERIS, ZCD2
Protein names and data: CISD2_HUMAN , CDGSH iron-sulfur domain-containing protein 2 , Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Miner1; Nutrient-deprivation autophagy factor-1; NAF-1 Lenght: 135 a.a.
Mass: 15278 Da
fasta formatted sequence
Function: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Disease:
Cellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
Tissue specificity: Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.

Database cross-references

UniProt: Q8N5K1
Ensembl: ENST00000273986
MIM: 604928
MIM: 611507
neXtProt: NX_Q8N5K1
Antibodypedia: Q8N5K1 (may not find the protein thus also not any antibody)
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