Source: hRBCD ; ID: IPI00010896
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: CLIC1 , G6, NCC27
Protein names and data: CLIC1_HUMAN , Chloride intracellular channel protein 1 , Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC Lenght: 241 a.a.
Mass: 26923 Da
fasta formatted sequence

Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Cellular location: Nucleus. Nucleus membrane; Single-pass membrane protein (Probable). Cytoplasm. Cell membrane; Single-pass membrane protein (Probable). Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
Tissue specificity: Expression is prominent in heart, placenta, liver, kidney and pancreas.

Database cross-references

UniProt: O00299
Ensembl: ENST00000375779
Ensembl: ENST00000375780
Ensembl: ENST00000375784
Ensembl: ENST00000383404
Ensembl: ENST00000383405
Ensembl: ENST00000395892
Ensembl: ENST00000400052
Ensembl: ENST00000400058
Ensembl: ENST00000415179
Ensembl: ENST00000418285
Ensembl: ENST00000420458
Ensembl: ENST00000422167
Ensembl: ENST00000423055
Ensembl: ENST00000423143
Ensembl: ENST00000423804
Ensembl: ENST00000425464
Ensembl: ENST00000431921
Ensembl: ENST00000433916
Ensembl: ENST00000434202
Ensembl: ENST00000435242
Ensembl: ENST00000438708
Ensembl: ENST00000438750
Ensembl: ENST00000442045
Ensembl: ENST00000447338
Ensembl: ENST00000447369
Ensembl: ENST00000451546
Ensembl: ENST00000456863
Ensembl: ENST00000457485
MIM: 602872
neXtProt: NX_O00299
Antibodypedia: O00299 (may not find the protein thus also not any antibody)
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