CND2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NCAPH , BRRN, BRRN1, CAPH, KIAA0074
Protein names and data: CND2_HUMAN , Condensin complex subunit 2 , Barren homolog protein 1; Chromosome-associated protein H; hCAP-H; Non-SMC condensin I complex subunit H; XCAP-H homolog Lenght: 741 a.a.
Mass: 82563 Da
fasta formatted sequence
Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Cellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Tissue specificity: Widely expressed at low level. Expressed in proliferating cells.

Genetic variants

Database cross-references

UniProt: Q15003
Ensembl: ENST00000240423
MIM: 602332
neXtProt: NX_Q15003
Antibodypedia: Q15003 (may not find the protein thus also not any antibody)
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