CO9_HUMAN

Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: C9
Protein names and data: CO9_HUMAN , Complement component C9; Complement component C9a; Complement component C9b; Flags: Precursor Lenght: 559 a.a.
Mass: 63173 Da
fasta formatted sequence

Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
Disease:
Cellular location: Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
Tissue specificity: Plasma.

Genetic variants

Database cross-references

UniProt: P02748
Ensembl: ENST00000263408
MIM: 120940
MIM: 613825
neXtProt: NX_P02748
Antibodypedia: P02748 (may not find the protein thus also not any antibody)
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