COASY_HUMAN
Source: hRBCD ; ID: IPI00184821PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: COASY , PSEC0106
Protein names and data: COASY_HUMAN , Bifunctional coenzyme A synthase; CoA synthase , NBP; POV-2; Phosphopantetheine adenylyltransferase; 2.7.7.3; Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT; Dephospho-CoA kinase; DPCK; 2.7.1.24; Dephosphocoenzyme A kinase; DPCOAK Lenght: 564 a.a.
Mass: 62329 Da
fasta formatted sequence
Function: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Catalytic activity: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. ATP + 3'-dephospho-CoA = ADP + CoA.
Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.
Cellular location: Cytoplasm (By similarity).
Tissue specificity: Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain.
Genetic variants
Database cross-references
UniProt: Q13057Ensembl: ENST00000393818
Ensembl: ENST00000420359
Ensembl: ENST00000421097
Ensembl: ENST00000449624
Ensembl: ENST00000590958
MIM: 609855
neXtProt: NX_Q13057
Antibodypedia: Q13057 (may not find the protein thus also not any antibody)
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