COF1_HUMAN

Source: hRBCD ; ID: IPI00012011
PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: CFL1 , CFL
Protein names and data: COF1_HUMAN , Cofilin-1 , 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform Lenght: 166 a.a.
Mass: 18502 Da
fasta formatted sequence
Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.
Cellular location: Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Tissue specificity: Widely distributed in various tissues.

Database cross-references

UniProt: P23528
Ensembl: ENST00000308162
Ensembl: ENST00000525451
MIM: 601442
neXtProt: NX_P23528
Antibodypedia: P23528 (may not find the protein thus also not any antibody)
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