COMT_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: COMT
Protein names and data: COMT_HUMAN , Catechol O-methyltransferase; 2.1.1.6 Lenght: 271 a.a.
Mass: 30037 Da
fasta formatted sequence
Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Catalytic activity: S-adenosyl-L-methionine + a catechol = S- adenosyl-L-homocysteine + a guaiacol.
Cellular location: Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.
Tissue specificity: Brain, liver, placenta, lymphocytes and erythrocytes.

Genetic variants

Two alleles, COMT*1 or COMT*H with Val-158 and COMT*2 or COMT*L with Met-158 are responsible for a three to four- fold difference in enzymatic activity. Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIM:103780].

Database cross-references

UniProt: P21964
Ensembl: ENST00000361682
Ensembl: ENST00000403710
Ensembl: ENST00000406520
Ensembl: ENST00000407537
Ensembl: ENST00000449653
MIM: 103780
MIM: 116790
neXtProt: NX_P21964
Antibodypedia: P21964 (may not find the protein thus also not any antibody)
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