COPD_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ARCN1 , COPD
Protein names and data: COPD_HUMAN , Coatomer subunit delta , Archain; Delta-coat protein; Delta-COP Lenght: 511 a.a.
Mass: 57210 Da
fasta formatted sequence
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Cellular location: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity).
Tissue specificity: Ubiquitously expressed.

Genetic variants

Database cross-references

UniProt: P48444
Ensembl: ENST00000264028
Ensembl: ENST00000392859
Ensembl: ENST00000593602
Ensembl: ENST00000596715
MIM: 600820
neXtProt: NX_P48444
Antibodypedia: P48444 (may not find the protein thus also not any antibody)
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