CP4F3_HUMAN

Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CYP4F3 , LTB4H
Protein names and data: CP4F3_HUMAN , Leukotriene-B(4) omega-hydroxylase 2; 1.14.13.30 , CYPIVF3; Cytochrome P450 4F3; Cytochrome P450-LTB-omega; Leukotriene-B(4) 20-monooxygenase 2 Lenght: 520 a.a.
Mass: 59847 Da
fasta formatted sequence
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH. Isoform CYP4F3A catalyzes the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. Isoform CYP4F3B: Has a 30-fold higher Km for LTB4 compared with CYP4F3A, but it utilizes arachidonic acid as a substrate for omega-hydroxylation and generates 20-HETE, an activator of kinases PKC and CK2.
Catalytic activity: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa- 6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)- 5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
Pathway: Lipid metabolism; leukotriene B4 degradation.
Cellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Microsome membrane; Single-pass membrane protein (By similarity).
Tissue specificity: Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract.

Genetic variants

Database cross-references

UniProt: Q08477
Ensembl: ENST00000221307
Ensembl: ENST00000585846
Ensembl: ENST00000586182
Ensembl: ENST00000591058
MIM: 601270
neXtProt: NX_Q08477
Antibodypedia: Q08477 (may not find the protein thus also not any antibody)
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