CP7A1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CYP7A1 , CYP7
Protein names and data: CP7A1_HUMAN , Cholesterol 7-alpha-monooxygenase; 1.14.13.17 , CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1 Lenght: 504 a.a.
Mass: 57661 Da
fasta formatted sequence
Function: Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.
Catalytic activity: Cholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O.
Pathway: Lipid metabolism; bile acid biosynthesis.
Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity: Detected in liver.

Genetic variants

Database cross-references

UniProt: P22680
Ensembl: ENST00000301645
MIM: 118455
neXtProt: NX_P22680
Antibodypedia: P22680 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.