CRK_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CRK
Protein names and data: CRK_HUMAN , Adapter molecule crk , Proto-oncogene c-Crk; p38 Lenght: 304 a.a.
Mass: 33831 Da
fasta formatted sequence
Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Cellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated to the plasma membrane upon cell adhesion (By similarity).

Database cross-references

UniProt: P46108
Ensembl: ENST00000300574
Ensembl: ENST00000398970
MIM: 164762
neXtProt: NX_P46108
Antibodypedia: P46108 (may not find the protein thus also not any antibody)
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